FungAMR: A comprehensive portrait of antimicrobial resistance mutations in fungi

The FungAMR reference dataset, curated from 462 papers, provides 54,666 mutation entries in fungal pathogens. The dataset covers 92 species, 202 genes, and 184 drugs. Combining variant effect predictors with FungAMR resistance mutations helps predict potential AMR impacts. Comparative analysis reveals high convergence in resistance molecular basis, leading to cross-resistance within antifungals and between classes. The computational tool, ChroQueTas, uses FungAMR to screen fungal genomes for AMR mutations.